Kalpana Pandit is the grand daughter of Ayurvedic physician Bhishagratna Ayurveda Vidwan Sri B. V. Pandit. After gaining M.B.B.S. degree, she obtained M.D. in internal medicine, from USA. She then worked as an emergency physician in U.S.A. She modeled for television commercials. products like Wheel detergent powder, Mysore sandal talc, Nyle, and Ranipal stain remover & Sirtex in India. In 2000, She made her acting debut with the Bollywood film Gaja Gamini directed by M. F. Husain.