Anjali was born in Razole, East Godavari District, Andhra Pradesh. She completed her schooling in Razole and later moved to Chennai, Tamil Nadu where she continued her studies, pursuing a degree in Mathematics. After completing her education, she began acting in short films, which paved the way for her entry into the film industry. Anjali remarked that her parents had aspirations to become an actor and that they "realised their dreams" through her.