Mistry first received acclaim for his work in filmAmrapali (1945), directed by Nandlal Jaswantlal.He was a stalwart of Navketan Films, after the critical acclaim of Guide (1967) directed by Vijay Anand, which also won him a Filmfare Award,Mistry worked in a number of films directed by his elder brother Dev Anand, including Prem Pujari (1970), Hare Rama Hare Krishna (1971), Heera Panna (1973), Ishq Ishq Ishq (1974), Des Pardes (1978).He directed three feature films, including, Jan Pahchan (1950), Armaan (1953) and Sazaa (1951) starring Dev Anand,The film also noted for its music by SD Burman in songs Tum Na Jaaney Kis Jehan Mein Kho Gaye sung by Lata Mangeshkar.he died in 1979.